Inhibition of growth of L-cystine crystals by N-acetyl-L-cysteine

Tingming Fu; Tongxin Wei; Yonghai Liu; Jie Jing; Yaqi Xu; Chunyan Ou; Yao Chen; Junsong Li; Bo Li; Huaxu Zhu

doi:10.1039/C6CE01749E

Inhibition of growth of l-cystine crystals by N-acetyl-l-cysteine†‡

Tingming Fu,*^ab Tongxin Wei,^a Yonghai Liu,^a Jie Jing,^a Yaqi Xu,^a Chunyan Ou,^a Yao Chen,^a Junsong Li,^a Bo Li^b and Huaxu Zhu^a

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^a School of Pharmacy, Nanjing University of Chinese Medicine, No. 138, XianlinDadao (210023), Nanjing, China
E-mail: futm@njucm.edu.cn

^b Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, No. 138, XianlinDadao (210023), Nanjing, China

Abstract

N-Acetyl-L-cysteine, a thiol drug used commonly as an expectorant, was used to inhibit the growth of L-cystine crystals. Dual effects of a chemical decomposition reaction and crystallization inhibition ensure that N-acetyl-L-cysteine has an unusual inhibitory effect on the growth of L-cystine crystals, and could aid its development as a new drug for the treatment of L-cystine stones.

CrystEngComm

Inhibition of growth of l-cystine crystals by N-acetyl-l-cysteine†‡

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Inhibition of growth of L-cystine crystals by N-acetyl-L-cysteine

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