Synthesis, structures and cytotoxicity studies of p-sulfonatocalixarene lanthanide complexes†
A number of p-sulfonatocalixarene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised. Crystal structure determinations reveal lanthanide coordination at the sulfonate group, bridging several calixarene units, giving coordination polymers. All complexes in this study have been determined to be relatively non-toxic using in vitro cell assays with CC50 values in the range 30–170 μM.
- This article is part of the themed collection: Form and Function of Molecular Cups and Capsules