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Issue 16, 2016
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Can we exchange water in a hydrate structure: a case study of etoricoxib

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Abstract

Novel crystalline forms of etoricoxib (ETR) with pharmaceutically acceptable coformers (generally regarded as safe, GRAS), such as glutaric acid (1 : 1), adipic acid (2 : 1), suberic acid (1 : 1), and caprolactam, were co-crystallized. The solid forms were prepared from ETR hemihydrate form I and characterized by powder XRD, DSC, and IR, and finally confirmed by single crystal X-ray diffraction. The exchange of water with an organic acid coformer in the crystal structure is explained by lattice energy calculations.

Graphical abstract: Can we exchange water in a hydrate structure: a case study of etoricoxib

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Publication details

The article was received on 01 Jan 2016, accepted on 25 Feb 2016 and first published on 25 Feb 2016


Article type: Paper
DOI: 10.1039/C6CE00003G
Citation: CrystEngComm, 2016,18, 2825-2829
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    Can we exchange water in a hydrate structure: a case study of etoricoxib

    S. Mittapalli, G. Bolla, S. Perumalla and A. Nangia, CrystEngComm, 2016, 18, 2825
    DOI: 10.1039/C6CE00003G

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