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Issue 69, 2016
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Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system

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Abstract

We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules. Release is mediated by a novel class of photochromic material – donor–acceptor Stenhouse adducts (DASAs). We demonstrate controlled delivery of small molecules such as the chemotherapeutic agent (paclitaxel) to human breast cancer cells triggered by micellar switching with low intensity, visible light.

Graphical abstract: Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system

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Article information


Submitted
16 May 2016
Accepted
01 Aug 2016
First published
01 Aug 2016

Chem. Commun., 2016,52, 10525-10528
Article type
Communication

Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system

S. O. Poelma, S. S. Oh, S. Helmy, A. S. Knight, G. L. Burnett, H. T. Soh, C. J. Hawker and J. Read de Alaniz, Chem. Commun., 2016, 52, 10525
DOI: 10.1039/C6CC04127B

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