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Issue 14, 2016
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Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging

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Abstract

A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized 13C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized 13C pH imaging in a phantom and in vivo in a murine model of prostate cancer.

Graphical abstract: Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging

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Supplementary files

Publication details

The article was received on 24 Nov 2015, accepted on 12 Jan 2016 and first published on 12 Jan 2016


Article type: Communication
DOI: 10.1039/C5CC09724J
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Chem. Commun., 2016,52, 3030-3033

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    Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging

    D. E. Korenchan, R. R. Flavell, C. Baligand, R. Sriram, K. Neumann, S. Sukumar, H. VanBrocklin, D. B. Vigneron, D. M. Wilson and J. Kurhanewicz, Chem. Commun., 2016, 52, 3030
    DOI: 10.1039/C5CC09724J

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