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Issue 25, 2016
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A fluorescent surrogate of thymidine in duplex DNA

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Abstract

DMAT is a new fluorescent thymidine mimic composed of 2′-deoxyuridine fused to dimethylaniline. DMAT exhibits the same pKa and base pairing characteristics as native thymidine residues, and its fluorescence properties are highly sensitive to nucleobase ionization, base pairing and metal binding.

Graphical abstract: A fluorescent surrogate of thymidine in duplex DNA

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Supplementary files

Article information


Submitted
18 Nov 2015
Accepted
25 Feb 2016
First published
25 Feb 2016

This article is Open Access

Chem. Commun., 2016,52, 4718-4721
Article type
Communication

A fluorescent surrogate of thymidine in duplex DNA

G. Mata, O. P. Schmidt and N. W. Luedtke, Chem. Commun., 2016, 52, 4718
DOI: 10.1039/C5CC09552B

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