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Issue 100, 2016
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Noncovalent and site-directed spin labeling of duplex RNA

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Abstract

An isoindoline-nitroxide derivative of guanine (Ǵ, “G-spin”) was shown to bind specifically and effectively to abasic sites in duplex RNAs. Distance measurements on a Ǵ-labeled duplex RNA with PELDOR (DEER) showed a strong orientation dependence. Thus, Ǵ is a readily synthesized, orientation-selective spin label for “mix and measure” PELDOR experiments.

Graphical abstract: Noncovalent and site-directed spin labeling of duplex RNA

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Publication details

The article was received on 18 Oct 2016, accepted on 23 Nov 2016 and first published on 30 Nov 2016


Article type: Communication
DOI: 10.1039/C6CC08387K
Citation: Chem. Commun., 2016,52, 14442-14445

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    Noncovalent and site-directed spin labeling of duplex RNA

    N. R. Kamble, M. Gränz, T. F. Prisner and S. Th. Sigurdsson, Chem. Commun., 2016, 52, 14442
    DOI: 10.1039/C6CC08387K

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