Issue 1, 2017
From the journal:

Chemical Communications

Synthesis of ramariolide natural products and discovery of their targets in mycobacteria†

Johannes Lehmann,a   Johannes Richers,b   Alexander Pöthigb  and  Stephan A. Sieber*a  

* Corresponding authors

a Department of Chemistry, Center for Integrated Protein Science Munich (CIPSM), Technische Universität München, Lichtenbergstraße 4, 85747 Garching, Germany
E-mail: stephan.sieber@tum.de

b Catalysis Research Center (CRC), Technische Universität München, Ernst-Otto-Fischer Straße 1, 85747 Garching, Germany

Abstract

Ramariolides A–D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential proteins for amino acid anabolism.

Graphical abstract: Synthesis of ramariolide natural products and discovery of their targets in mycobacteria

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Article information

DOI
https://doi.org/10.1039/C6CC08365J
Article type
Communication
Submitted
17 Oct 2016
Accepted
11 Nov 2016
First published
11 Nov 2016
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2017,53, 107-110

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Synthesis of ramariolide natural products and discovery of their targets in mycobacteria

J. Lehmann, J. Richers, A. Pöthig and S. A. Sieber, Chem. Commun., 2017, 53, 107 DOI: 10.1039/C6CC08365J

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