Two trigeminal star-like platinum complexes were synthesized to induce the formation of human telomere G-quadruplex (hTel G4) with extremely high selectivity and affinity. The induced hTel G4 activates strong telomeric DNA damage response (TDDR), resulting in telomere dysfunction and cell senescence.
X. Zheng, G. Mu, Y. Zhong, T. Zhang, Q. Cao, L. Ji, Y. Zhao and Z. Mao, Chem. Commun., 2016, 52, 14101 DOI: 10.1039/C6CC08254H
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