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Issue 98, 2016
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Tetracyclic dihydronaphthalene derivatives via gold-catalyzed aminative homodimerization of ortho-alkynylbenzaldehydes

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Abstract

Gold(I) catalyzes domino homodimerization of o-alkynylbenzaldehydes via a sequence of 6-endo-dig-cyclization, amine addition, and [4+2] cycloaddition involving two bicyclic intermediates. The resulting products integrate medicinally relevant 1,2-dihydronaphthalene and isochromene moieties into a single amine-substituted tetracyclic framework.

Graphical abstract: Tetracyclic dihydronaphthalene derivatives via gold-catalyzed aminative homodimerization of ortho-alkynylbenzaldehydes

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Publication details

The article was received on 08 Oct 2016, accepted on 15 Nov 2016 and first published on 15 Nov 2016


Article type: Communication
DOI: 10.1039/C6CC08132K
Citation: Chem. Commun., 2016,52, 14133-14136
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    Tetracyclic dihydronaphthalene derivatives via gold-catalyzed aminative homodimerization of ortho-alkynylbenzaldehydes

    A. A. Ruch, F. Kong, V. N. Nesterov and L. M. Slaughter, Chem. Commun., 2016, 52, 14133
    DOI: 10.1039/C6CC08132K

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