Issue 98, 2016
From the journal:

Chemical Communications

Tetracyclic dihydronaphthalene derivatives via gold-catalyzed aminative homodimerization of ortho-alkynylbenzaldehydes†

Aaron A. Ruch,a   Fanji Kong,a   Vladimir N. Nesterova  and  LeGrande M. Slaughter ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of North Texas, 1155 Union Circle #305070, Denton, Texas, USA
E-mail: legrande@unt.edu

Abstract

Gold(I) catalyzes domino homodimerization of o-alkynylbenzaldehydes via a sequence of 6-endo-dig-cyclization, amine addition, and [4+2] cycloaddition involving two bicyclic intermediates. The resulting products integrate medicinally relevant 1,2-dihydronaphthalene and isochromene moieties into a single amine-substituted tetracyclic framework.

Graphical abstract: Tetracyclic dihydronaphthalene derivatives via gold-catalyzed aminative homodimerization of ortho-alkynylbenzaldehydes

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Article information

DOI
https://doi.org/10.1039/C6CC08132K
Article type
Communication
Submitted
08 Oct 2016
Accepted
15 Nov 2016
First published
15 Nov 2016

Chem. Commun., 2016,52, 14133-14136

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Tetracyclic dihydronaphthalene derivatives via gold-catalyzed aminative homodimerization of ortho-alkynylbenzaldehydes

A. A. Ruch, F. Kong, V. N. Nesterov and L. M. Slaughter, Chem. Commun., 2016, 52, 14133 DOI: 10.1039/C6CC08132K

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