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Issue 84, 2016
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Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks

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Abstract

The potential of deuterated pharmaceuticals is being widely demonstrated. Here we describe the first trideuteromethylation under radical reaction conditions using deuterated dimethyl sulfoxide as a reagent for the synthesis of labelled heterocycles and trideuteromethylated compounds. A broad scope of the developed method for the synthesis of various scaffolds was demonstrated.

Graphical abstract: Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks

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Publication details

The article was received on 02 Sep 2016, accepted on 23 Sep 2016 and first published on 26 Sep 2016


Article type: Communication
DOI: 10.1039/C6CC07196A
Citation: Chem. Commun., 2016,52, 12486-12489
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    Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks

    R. Caporaso, S. Manna, S. Zinken, A. R. Kochnev, E. R. Lukyanenko, A. V. Kurkin and A. P. Antonchick, Chem. Commun., 2016, 52, 12486
    DOI: 10.1039/C6CC07196A

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