Issue 83, 2016
From the journal:

Chemical Communications

Nebraska Red: a phosphinate-based near-infrared fluorophore scaffold for chemical biology applications†

Xinqi Zhou,a   Rui Lai,ab   Jon R. Beck,a   Hui Liab  and  Cliff I. Stains*a  

* Corresponding authors

a Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA
E-mail: cstains2@unl.edu

b Nebraska Center for Materials and Nanoscience, University of Nebraska-Lincoln, Lincoln, NE 68588, USA

Abstract

A series of novel phosphinate-based dyes displaying near-infrared fluorescence (NIR) are reported. These dyes exhibit remarkable photostability and brightness. The phosphinate functionality is leveraged as an additional reactive handle in order to tune cell permeability as well as provide a proof-of-principle for a self-reporting small molecule delivery vehicle.

Graphical abstract: Nebraska Red: a phosphinate-based near-infrared fluorophore scaffold for chemical biology applications

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Article information

DOI
https://doi.org/10.1039/C6CC05717A
Article type
Communication
Submitted
11 Jul 2016
Accepted
09 Sep 2016
First published
09 Sep 2016

Chem. Commun., 2016,52, 12290-12293

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Nebraska Red: a phosphinate-based near-infrared fluorophore scaffold for chemical biology applications

X. Zhou, R. Lai, J. R. Beck, H. Li and C. I. Stains, Chem. Commun., 2016, 52, 12290 DOI: 10.1039/C6CC05717A

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