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Issue 67, 2016
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3D structure determination of a protein in living cells using paramagnetic NMR spectroscopy

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Abstract

Determining the three-dimensional structure of a protein in living cells remains particularly challenging. We demonstrated that the integration of site-specific tagging proteins and GPS-Rosetta calculations provides a fast and effective way of determining the structures of proteins in living cells, and in principle the interactions and dynamics of protein–ligand complexes.

Graphical abstract: 3D structure determination of a protein in living cells using paramagnetic NMR spectroscopy

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Article information


Submitted
04 Jul 2016
Accepted
20 Jul 2016
First published
20 Jul 2016

Chem. Commun., 2016,52, 10237-10240
Article type
Communication

3D structure determination of a protein in living cells using paramagnetic NMR spectroscopy

B. Pan, F. Yang, Y. Ye, Q. Wu, C. Li, T. Huber and X. Su, Chem. Commun., 2016, 52, 10237
DOI: 10.1039/C6CC05490K

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