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Issue 83, 2016
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An efficient construction of N,N-bicyclic pyrazolidinones comprising enaminonitriles via asymmetric [3+2] cycloaddition

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Abstract

The first thiourea catalysed asymmetric [3+2] cycloaddition reaction between azomethine imines and malanonitriles was developed. Using this novel synthetic strategy, hybrid molecules containing N,N-bicyclic pyrazolidinones fused with enaminonitriles were synthesized in good yields with excellent enantioselectivities (up to 98% ee).

Graphical abstract: An efficient construction of N,N-bicyclic pyrazolidinones comprising enaminonitriles via asymmetric [3+2] cycloaddition

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Publication details

The article was received on 25 Jun 2016, accepted on 16 Sep 2016 and first published on 19 Sep 2016


Article type: Communication
DOI: 10.1039/C6CC05304A
Chem. Commun., 2016,52, 12314-12317

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    An efficient construction of N,N-bicyclic pyrazolidinones comprising enaminonitriles via asymmetric [3+2] cycloaddition

    M. Vishwanath, K. Sivamuthuraman and V. Kesavan, Chem. Commun., 2016, 52, 12314
    DOI: 10.1039/C6CC05304A

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