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Issue 60, 2016
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Synthesis of photoactivatable azido-acyl caged oxazine fluorophores for live-cell imaging

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Abstract

We report the design and synthesis of a photoactivatable azido-acyl oxazine fluorophore. Photoactivation is achieved cleanly and rapidly with UV light, producing a single fluorescent oxazine photoproduct. We demonstrate the utility of azido-acyl caged oxazines for protein specific labeling in living mammalian cells using the TMP-tag technology.

Graphical abstract: Synthesis of photoactivatable azido-acyl caged oxazine fluorophores for live-cell imaging

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Publication details

The article was received on 10 Jun 2016, accepted on 01 Jul 2016 and first published on 01 Jul 2016


Article type: Communication
DOI: 10.1039/C6CC04882J
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Chem. Commun., 2016,52, 9442-9445

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    Synthesis of photoactivatable azido-acyl caged oxazine fluorophores for live-cell imaging

    A. V. Anzalone, Z. Chen and V. W. Cornish, Chem. Commun., 2016, 52, 9442
    DOI: 10.1039/C6CC04882J

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