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Issue 66, 2016
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Host–guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents

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Abstract

Post-translational methylation is a chemically simple modification, but regulates the function of hundreds of proteins in profound ways. This Feature Article will report on the basic aspects of protein methylation, and will offer a personal perspective on our recent efforts at making supramolecular hosts that can bind and discriminate among post-translationally methylated partners. The article highlights several general lessons drawn from these efforts and related work by other groups. It also describes some ways in which supramolecular approaches are inherently well suited to provide tools that drive new research in the life sciences.

Graphical abstract: Host–guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents

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Publication details

The article was received on 07 Jun 2016, accepted on 28 Jun 2016 and first published on 29 Jun 2016


Article type: Feature Article
DOI: 10.1039/C6CC04771H
Citation: Chem. Commun., 2016,52, 10093-10108
  • Open access: Creative Commons BY-NC license
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    Host–guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents

    F. Hof, Chem. Commun., 2016, 52, 10093
    DOI: 10.1039/C6CC04771H

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