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Issue 55, 2016
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Predictive recognition of native proteins by cucurbit[7]uril in a complex mixture

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Abstract

The recognition of human growth hormone (hGH) by the synthetic host molecule cucurbit[7]uril (Q7) was predicted on the basis of its N-terminal phenylalanine. An aqueous-compatible resin with covalently immobilized Q7 groups was prepared and shown to recognize native insulin and hGH in simple and complex mixtures.

Graphical abstract: Predictive recognition of native proteins by cucurbit[7]uril in a complex mixture

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Supplementary files

Article information


Submitted
16 Apr 2016
Accepted
10 Jun 2016
First published
10 Jun 2016

Chem. Commun., 2016,52, 8537-8540
Article type
Communication

Predictive recognition of native proteins by cucurbit[7]uril in a complex mixture

W. Li, A. T. Bockus, B. Vinciguerra, L. Isaacs and A. R. Urbach, Chem. Commun., 2016, 52, 8537
DOI: 10.1039/C6CC03193E

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