Plasmonic nanohalo optical probes for highly sensitive imaging of survivin mRNA in living cells†
Abstract
A strategy is designed for sensitive detection of tumor biomarker survivin mRNA based on resonance Rayleigh scattering of a single AuNP nanohalo probe that couples large gold nanoparticles (L-AuNPs, 52 nm) with small AuNPs (S-AuNPs, 18 nm) through the affinity interaction between streptavidin and biotin. This core–satellite plasmon ruler is further applied to imaging survivin mRNA in living cells.