Issue 74, 2016
From the journal:

Chemical Communications

Plasmonic nanohalo optical probes for highly sensitive imaging of survivin mRNA in living cells†

Guang-Sheng Qian,a   Bin Kang,a   Zhuo-Lei Zhang,a   Xiang-Ling Li,a   Wei Zhao,*a   Jing-Juan Xu*a  and  Hong-Yuan Chena  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
E-mail: weizhao@nju.edu.cn, xujj@nju.edu.cn
Fax: +86-25-89687294
Tel: +86-25-89687294

Abstract

A strategy is designed for sensitive detection of tumor biomarker survivin mRNA based on resonance Rayleigh scattering of a single AuNP nanohalo probe that couples large gold nanoparticles (L-AuNPs, 52 nm) with small AuNPs (S-AuNPs, 18 nm) through the affinity interaction between streptavidin and biotin. This core–satellite plasmon ruler is further applied to imaging survivin mRNA in living cells.

Graphical abstract: Plasmonic nanohalo optical probes for highly sensitive imaging of survivin mRNA in living cells

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Article information

DOI
https://doi.org/10.1039/C6CC02831D
Article type
Communication
Submitted
05 Apr 2016
Accepted
06 Jul 2016
First published
06 Jul 2016

Chem. Commun., 2016,52, 11052-11055

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Plasmonic nanohalo optical probes for highly sensitive imaging of survivin mRNA in living cells

G. Qian, B. Kang, Z. Zhang, X. Li, W. Zhao, J. Xu and H. Chen, Chem. Commun., 2016, 52, 11052 DOI: 10.1039/C6CC02831D

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