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Issue 37, 2016
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Dioxazoles, a new mild nitrene transfer reagent in gold catalysis: highly efficient synthesis of functionalized oxazoles

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Abstract

A gold-catalyzed regioselective [3+2] cycloaddition of ynamides with 1,4,2-dioxazoles was developed and offers a novel approach to obtain highly functionalized oxazoles under mild reaction conditions. 1,4,2-Dioxazole was found to act as an efficient N-acyl nitrene equivalent to trigger a facile generation of α-imino gold–carbene intermediate through the elimination of a ketone.

Graphical abstract: Dioxazoles, a new mild nitrene transfer reagent in gold catalysis: highly efficient synthesis of functionalized oxazoles

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Supplementary files

Article information


Submitted
09 Mar 2016
Accepted
04 Apr 2016
First published
04 Apr 2016

This article is Open Access

Chem. Commun., 2016,52, 6324-6327
Article type
Communication

Dioxazoles, a new mild nitrene transfer reagent in gold catalysis: highly efficient synthesis of functionalized oxazoles

M. Chen, N. Sun, H. Chen and Y. Liu, Chem. Commun., 2016, 52, 6324
DOI: 10.1039/C6CC02776H

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