Issue 49, 2016
From the journal:

Chemical Communications

PEG stabilized DNA – poly(ferrocenylsilane) polyplexes for gene delivery†

B. Zoetebier,a   A. Sohrabi,ab   B. Lou,c   M. A. Hempenius,a   W. E. Hennink*c  and  G. J. Vancso*a  

* Corresponding authors

a Department of Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands
E-mail: G.J.Vancso@utwente.nl

b Department of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, P.O. Box 951600, Los Angeles, CA 90095, USA

c Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands
E-mail: W.E.Hennink@uu.nl

Abstract

Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.

Graphical abstract: PEG stabilized DNA – poly(ferrocenylsilane) polyplexes for gene delivery

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Article information

DOI
https://doi.org/10.1039/C6CC02733D
Article type
Communication
Submitted
31 Mar 2016
Accepted
19 May 2016
First published
19 May 2016

Chem. Commun., 2016,52, 7707-7710

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PEG stabilized DNA – poly(ferrocenylsilane) polyplexes for gene delivery

B. Zoetebier, A. Sohrabi, B. Lou, M. A. Hempenius, W. E. Hennink and G. J. Vancso, Chem. Commun., 2016, 52, 7707 DOI: 10.1039/C6CC02733D

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