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Issue 63, 2016
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Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (<250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry

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Abstract

A novel vacuum stable proton sponge, 4-maleicanhydridoproton sponge (MAPS), was prepared and applied as the matrix in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) of an aggressive brain tumor tissue (glioblastoma multiforme). Ionic maps of lactate, 2-hydroxyglutarate and chloride anions (m/z 89, 147, 35, respectively) were obtained using a routine MALDI ToF mass spectrometer.

Graphical abstract: Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (<250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry

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Publication details

The article was received on 18 Mar 2016, accepted on 04 Jul 2016 and first published on 05 Jul 2016


Article type: Communication
DOI: 10.1039/C6CC02387H
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Citation: Chem. Commun., 2016,52, 9801-9804

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    Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (<250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry

    M. Giampà, M. B. Lissel, T. Patschkowski, J. Fuchser, V. H. Hans, O. Gembruch, H. Bednarz and K. Niehaus, Chem. Commun., 2016, 52, 9801
    DOI: 10.1039/C6CC02387H

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