Self-assembled nanofiber hydrogels for mechanoresponsive therapeutic anti-TNFα antibody delivery

Abstract

Low molecular weight hydrogels, prepared from glycosyl–nucleoside–lipid amphiphiles, exhibit shear-thinning behaviour and reversible thermally- and mechanically-triggered sol–gel transitions. Using mechanical shear stimulation, the release of entrapped anti-TNFα increases and the released anti-TNFα demonstrates efficacy in in vitro neutralization bioassays. Delivery of anti-TNFα is of general interest and broad medicinal utility for treating autoimmune diseases such as rheumatoid arthritis.