Issue 43, 2016

bcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules

Abstract

Dynamic nuclear polarization (DNP) is an efficient method to overcome the inherent low sensitivity of magic-angle spinning (MAS) solid-state NMR. We report a new polarizing agent (bcTol), designed for biological applications, that yielded an enhancement value of 244 in a microcrystalline SH3 domain sample at 110 K.

Graphical abstract: bcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules

Supplementary files

Article information

Article type
Communication
Submitted
29 Feb 2016
Accepted
03 May 2016
First published
10 May 2016

Chem. Commun., 2016,52, 7020-7023

Author version available

bcTol: a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules

A. P. Jagtap, M. Geiger, D. Stöppler, M. Orwick-Rydmark, H. Oschkinat and S. Th. Sigurdsson, Chem. Commun., 2016, 52, 7020 DOI: 10.1039/C6CC01813K

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