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Issue 26, 2016
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Study and application of noncatalyzed photoinduced conjugation of azides and cycloocta-1,2,3-selenadiazoles

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Abstract

The non-catalyzed cycloaddition of eight structurally different azides with cyclooctyne generated in situ by the photolysis of cycloocta-1,2,3-selenadiazole gives 1,2,3-triazole derivatives as the main products. The application of this reaction was demonstrated by the photoconjugation reaction of cycloocta-1,2,3-selenadiazole with an avidin-modified biotin complex to introduce a new strategy in the non-catalyzed synthesis of bioconjugates.

Graphical abstract: Study and application of noncatalyzed photoinduced conjugation of azides and cycloocta-1,2,3-selenadiazoles

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Article information


Submitted
28 Feb 2016
Accepted
01 Mar 2016
First published
02 Mar 2016

Chem. Commun., 2016,52, 4792-4795
Article type
Communication

Study and application of noncatalyzed photoinduced conjugation of azides and cycloocta-1,2,3-selenadiazoles

P. Jedináková, P. Šebej, T. Slanina, P. Klán and J. Hlaváč, Chem. Commun., 2016, 52, 4792
DOI: 10.1039/C6CC01789D

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