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Issue 46, 2016
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Isomorphous template induced crystallisation: a robust method for the targeted crystallisation of computationally predicted metastable polymorphs

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Abstract

A new method of inducing the crystallisation of metastable polymorphs by isomorphous templating has been developed and used to reproduce the crystallisation of CBZ-V on the surface of DHC-II. Studies of the growth of CBZ-V on DHC-II single crystals show crystals growing laterally and vertically on DHC-II surfaces without any significant face selectivity. The generality of this computationally inspired crystallisation approach is demonstrated by producing the first crystals of an entirely new polymorph of cyheptamide, which is isomorphous to both DHC-II and CBZ-V.

Graphical abstract: Isomorphous template induced crystallisation: a robust method for the targeted crystallisation of computationally predicted metastable polymorphs

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Supplementary files

Article information


Submitted
25 Feb 2016
Accepted
05 May 2016
First published
05 May 2016

Chem. Commun., 2016,52, 7384-7386
Article type
Communication

Isomorphous template induced crystallisation: a robust method for the targeted crystallisation of computationally predicted metastable polymorphs

V. K. Srirambhatla, R. Guo, S. L. Price and A. J. Florence, Chem. Commun., 2016, 52, 7384
DOI: 10.1039/C6CC01710J

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