Issue 22, 2016
From the journal:

Chemical Communications

DNA base-stacking assay utilizing catalytic hairpin assembly-induced gold nanoparticle aggregation for colorimetric protein sensing†

Chia-Chen Chang, ORCID logo a   Chie-Pein Chen,b   Chen-Yu Chen*bc  and  Chii-Wann Lin*ade  

* Corresponding authors

a Institute of Biomedical Engineering, National Taiwan University, Taipei 106, Taiwan, Republic of China
E-mail: cwlinx@ntu.edu.tw
Fax: +886-2-23620586
Tel: +886-2-33665271

b Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei 104, Taiwan, Republic of China
E-mail: f122481@mmh.org.tw

c Department of Medicine, Mackay Medical College, Taipei 252, Taiwan, Republic of China

d Institute of Biomedical Electronic and Bioinformatics, National Taiwan University, Taipei 106, Taiwan, Republic of China

e Center for Emerging Material and Advanced Devices, National Taiwan University, Taipei 106, Taiwan, Republic of China

Abstract

A label-free and enzyme-free colorimetric sensing platform for the amplified detection of fibronectin was developed based on an ingenious combination of catalytic hairpin assembly and a base stacking hybridization-based gold nanoparticle aggregation strategy. The detection limit of 2.3 pM is at least one order of magnitude lower than that of established fibronectin biosensors.

Graphical abstract: DNA base-stacking assay utilizing catalytic hairpin assembly-induced gold nanoparticle aggregation for colorimetric protein sensing

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Article information

DOI
https://doi.org/10.1039/C6CC01238H
Article type
Communication
Submitted
08 Feb 2016
Accepted
16 Feb 2016
First published
16 Feb 2016

Chem. Commun., 2016,52, 4167-4170

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DNA base-stacking assay utilizing catalytic hairpin assembly-induced gold nanoparticle aggregation for colorimetric protein sensing

C. Chang, C. Chen, C. Chen and C. Lin, Chem. Commun., 2016, 52, 4167 DOI: 10.1039/C6CC01238H

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