Issue 35, 2016
From the journal:

Chemical Communications

An electrochemical peptide cleavage-based biosensor for matrix metalloproteinase-2 detection with exonuclease III-assisted cycling signal amplification†

Ding Wang,a   Yali Yuan,a   Yingning Zheng,a   Yaqin Chai*a  and  Ruo Yuan*a  

* Corresponding authors

a Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
E-mail: yqchai@swu.edu.cn, yuanruo@swu.edu.cn
Fax: +86-23-68253172
Tel: +86-023-68252277

Abstract

In this work, an electrochemical peptide biosensor was developed for matrix metalloproteinase-2 (MMP-2) detection by conversion of a peptide cleavage event into DNA detection with exonuclease III (Exo III)-assisted cycling signal amplification.

Graphical abstract: An electrochemical peptide cleavage-based biosensor for matrix metalloproteinase-2 detection with exonuclease III-assisted cycling signal amplification

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Article information

DOI
https://doi.org/10.1039/C6CC00928J
Article type
Communication
Submitted
29 Jan 2016
Accepted
23 Mar 2016
First published
25 Mar 2016

Chem. Commun., 2016,52, 5943-5945

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An electrochemical peptide cleavage-based biosensor for matrix metalloproteinase-2 detection with exonuclease III-assisted cycling signal amplification

D. Wang, Y. Yuan, Y. Zheng, Y. Chai and R. Yuan, Chem. Commun., 2016, 52, 5943 DOI: 10.1039/C6CC00928J

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