[11C]Ascorbic and [11C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography

V. N. Carroll; C. Truillet; B. Shen; R. R. Flavell; X. Shao; M. J. Evans; H. F. VanBrocklin; P. J. H. Scott; F. T. Chin; D. M. Wilson

doi:10.1039/C6CC00895J

[¹¹C]Ascorbic and [¹¹C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography†

V. N. Carroll,^a C. Truillet,^a B. Shen,^b R. R. Flavell,

^a X. Shao,^c M. J. Evans,^a H. F. VanBrocklin,^a P. J. H. Scott,*^c F. T. Chin*^b and D. M. Wilson*^a

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* Corresponding authors

^a Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94107, USA
E-mail: David.M.Wilson@ucsf.edu

^b The Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, California 94305, USA
E-mail: ChinF@Stanford.edu

^c Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
E-mail: PJHScott@umich.edu

Abstract

Here we report the radiosynthesis of an endogenous redox pair, [¹¹C]ascorbic acid ([¹¹C]VitC) and [¹¹C]dehydroascorbic acid ([¹¹C]DHA), the reduced and oxidized forms of vitamin C, and their application to ROS sensing. These results provide the basis for in vivo detection of ROS using positron emission tomography (PET).

Chemical Communications

[¹¹C]Ascorbic and [¹¹C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography†

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[¹¹C]Ascorbic and [¹¹C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography

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