Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 27, 2016
Previous Article Next Article

Dynamic foldamer chemistry

Author affiliations


Foldamers can be made more than pieces of static, conformationally uniform molecular architecture by designing into their structure the conformational dynamism characteristic of functional molecular machines. We show that these dynamic foldamers display biomimetic properties reminiscent of allosteric proteins and receptor molecules. They can translate chemical signals into conformational changes, and hence into chemical outputs such as control of reactivity and selectivity. Future developments could see dynamic foldamers operating in the membrane phase providing artificial mechanisms for communication and control that integrate synthetic chemistry into synthetic biology.

Graphical abstract: Dynamic foldamer chemistry

  • This article is part of the themed collection: Foldamers
Back to tab navigation

Publication details

The article was received on 26 Jan 2016, accepted on 01 Mar 2016 and first published on 02 Mar 2016

Article type: Feature Article
DOI: 10.1039/C6CC00788K
Author version
Download author version (PDF)
Citation: Chem. Commun., 2016,52, 4852-4863
  • Open access: Creative Commons BY license
  •   Request permissions

    Dynamic foldamer chemistry

    B. A. F. Le Bailly and J. Clayden, Chem. Commun., 2016, 52, 4852
    DOI: 10.1039/C6CC00788K

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author