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Issue 27, 2016
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Dynamic foldamer chemistry

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Abstract

Foldamers can be made more than pieces of static, conformationally uniform molecular architecture by designing into their structure the conformational dynamism characteristic of functional molecular machines. We show that these dynamic foldamers display biomimetic properties reminiscent of allosteric proteins and receptor molecules. They can translate chemical signals into conformational changes, and hence into chemical outputs such as control of reactivity and selectivity. Future developments could see dynamic foldamers operating in the membrane phase providing artificial mechanisms for communication and control that integrate synthetic chemistry into synthetic biology.

Graphical abstract: Dynamic foldamer chemistry

  • This article is part of the themed collection: Foldamers
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Publication details

The article was received on 26 Jan 2016, accepted on 01 Mar 2016 and first published on 02 Mar 2016


Article type: Feature Article
DOI: 10.1039/C6CC00788K
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Citation: Chem. Commun., 2016,52, 4852-4863
  • Open access: Creative Commons BY license
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    Dynamic foldamer chemistry

    B. A. F. Le Bailly and J. Clayden, Chem. Commun., 2016, 52, 4852
    DOI: 10.1039/C6CC00788K

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