Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 31, 2016
Previous Article Next Article

Small molecule-mediated duplex formation of nucleic acids with ‘incompatible’ backbones

Author affiliations

Abstract

Proflavine, a known intercalator of DNA and RNA, promotes duplex formation by nucleic acids with natural and non-natural backbones that otherwise form duplexes with low thermal stability, and even some that show no sign of duplex formation in the absence of proflavine. These findings demonstrate the potential for intercalators to be used as cofactors for the assembly of rationally designed nucleic acid structures, and could provide fundamental insights regarding intercalation of natural nucleic acid duplexes.

Graphical abstract: Small molecule-mediated duplex formation of nucleic acids with ‘incompatible’ backbones

  • This article is part of the themed collection: Foldamers
Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Jan 2016, accepted on 09 Mar 2016 and first published on 09 Mar 2016


Article type: Communication
DOI: 10.1039/C6CC00779A
Citation: Chem. Commun., 2016,52, 5436-5439

  •   Request permissions

    Small molecule-mediated duplex formation of nucleic acids with ‘incompatible’ backbones

    B. J. Cafferty, C. Musetti, K. Kim, E. D. Horowitz, R. Krishnamurthy and N. V. Hud, Chem. Commun., 2016, 52, 5436
    DOI: 10.1039/C6CC00779A

Search articles by author

Spotlight

Advertisements