Issue 16, 2016

Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination

Abstract

We report on a straightforward strategy to fabricate bioactive glycosylated gold nanoparticles via a combination of RAFT polymerization, carbohydrate ligation through reductive amination and thiol–gold self-assembly. This approach is used for the design of gold nanoparticles decorated with the complex sialylated glycan Neu5Ac-α-2-6-Gal, and we demonstrate multivalent and specific recognition between the nanoparticles, lectins and hemagglutinin on the surface of the influenza virus.

Graphical abstract: Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination

Supplementary files

Article information

Article type
Communication
Submitted
19 Jan 2016
Accepted
25 Jan 2016
First published
25 Jan 2016

Chem. Commun., 2016,52, 3352-3355

Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination

Z. Zhang, B. Schepens, L. Nuhn, X. Saelens, M. Schotsaert, N. Callewaert, R. De Rycke, Q. Zhang, S. Moins, S. Benali, L. Mespouille, R. Hoogenboom and B. G. De Geest, Chem. Commun., 2016, 52, 3352 DOI: 10.1039/C6CC00501B

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