Rhodium(iii)-catalyzed sp2 C–H bond addition to CF3-substituted unsaturated ketones

Abstract

Rhodium(III)-catalyzed conjugate addition of aromatic and olefinic C–H bonds to CF₃-substituted unsaturated ketones was efficiently achieved. Both arene and olefin substrates bearing a chelate assisted-directing group were coupled with a variety of β-trifluoromethyl-α,β-unsaturated ketones with excellent atom-economy, high yields, and broad substrate scopes.