Issue 15, 2016
From the journal:

Chemical Communications

A practical cobalt-catalyzed cross-coupling of benzylic zinc reagents with aryl and heteroaryl bromides or chlorides†

Andreas D. Benischke,a   Irina Knoll,a   Alice Rérat,b   Corinne Gosminib  and  Paul Knochel*a  

* Corresponding authors

a Department Chemie und Biochemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, D-81377 München, Germany
E-mail: knoch@cup.uni-muenchen.de
Fax: +49-89-2180-77680
Tel: +49-89-2180-77681

b Laboratoire de Chimie Moléculaire, CNRS, Ecole Polytechnique, Université Paris Saclay, 91128 Palaiseau, France
E-mail: corinnne.gosmini@polytechnique.edu
Fax: +33-1-6933-4440
Tel: +33-1-6933-4412

Abstract

A catalytic system consisting of 5 mol% CoCl2 and 10 mol% isoquinoline allows a convenient cross-coupling of benzylic zinc reagents with various aryl and heteroaryl bromides or chlorides leading to polyfunctionalized diaryl- and aryl-heteroaryl-methane derivatives.

Graphical abstract: A practical cobalt-catalyzed cross-coupling of benzylic zinc reagents with aryl and heteroaryl bromides or chlorides

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Article information

DOI
https://doi.org/10.1039/C5CC10272C
Article type
Communication
Submitted
14 Dec 2015
Accepted
20 Jan 2016
First published
20 Jan 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 3171-3174

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A practical cobalt-catalyzed cross-coupling of benzylic zinc reagents with aryl and heteroaryl bromides or chlorides

A. D. Benischke, I. Knoll, A. Rérat, C. Gosmini and P. Knochel, Chem. Commun., 2016, 52, 3171 DOI: 10.1039/C5CC10272C

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