A Cu-mediated one-pot Michael addition/α-arylation strategy using a diaryliodonium salt: a direct and efficient approach to α-aryl-β-substituted cyclic ketone scaffolds

Abstract

The direct and efficient construction of α-aryl-β-substituted cyclic ketone scaffolds has been achieved using a Cu-mediated one-pot Michael addition/α-arylation strategy. The reaction features easily available materials, broad substrate scope, moderate to good yield, and an excellent diastereoselectivity.