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Issue 15, 2016
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Versatile synthesis of cationic N-heterocyclic carbene–gold(i) complexes containing a second ancillary ligand. Design of heterobimetallic ruthenium–gold anticancer agents

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Abstract

We describe a versatile and quick route to cationic gold(I) complexes containing N-heterocyclic carbenes and a second ancillary ligand (such as phosphanes, phosphites, arsines and amines) of interest for the synthesis of compounds with potential catalytic and medicinal applications. The general synthetic strategy has been applied in the preparation of novel cationic heterobimetallic ruthenium(II)–gold(I) complexes that are highly cytotoxic to renal cancer Caki-1 and colon cancer HCT 116 cell lines while showing a synergistic effect and being more selective than their monometallic counterparts.

Graphical abstract: Versatile synthesis of cationic N-heterocyclic carbene–gold(i) complexes containing a second ancillary ligand. Design of heterobimetallic ruthenium–gold anticancer agents

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Supplementary files

Article information


Submitted
24 Nov 2015
Accepted
14 Jan 2016
First published
25 Jan 2016

Chem. Commun., 2016,52, 3155-3158
Article type
Communication
Author version available

Versatile synthesis of cationic N-heterocyclic carbene–gold(I) complexes containing a second ancillary ligand. Design of heterobimetallic ruthenium–gold anticancer agents

J. Fernández-Gallardo, B. T. Elie, M. Sanaú and M. Contel, Chem. Commun., 2016, 52, 3155
DOI: 10.1039/C5CC09718E

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