Issue 11, 2016
From the journal:

Chemical Communications

Affinity-based release of polymer-binding peptides from hydrogels with the target segments of peptides†

Takeshi Serizawa,*a   Hiroki Fukuta,a   Takaaki Datea  and  Toshiki Sawadaa  

* Corresponding authors

a Department of Organic and Polymeric Materials, Tokyo Institute of Technology, 2-12-1-H121 Ookayama, Meguro-ku, Tokyo 152-8550, Japan
E-mail: serizawa@polymer.titech.ac.jp

Abstract

Peptides with affinities for the target segments of polymer hydrogels were identified by biological screening using phage-displayed peptide libraries, and these peptides exhibited an affinity-based release capability from hydrogels. The results from cell culture assays demonstrated the sustained anticancer effects of the drug-conjugated peptides that were released from the hydrogels.

Graphical abstract: Affinity-based release of polymer-binding peptides from hydrogels with the target segments of peptides

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Article information

DOI
https://doi.org/10.1039/C5CC09016D
Article type
Communication
Submitted
30 Oct 2015
Accepted
18 Nov 2015
First published
18 Nov 2015

Chem. Commun., 2016,52, 2241-2244

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Affinity-based release of polymer-binding peptides from hydrogels with the target segments of peptides

T. Serizawa, H. Fukuta, T. Date and T. Sawada, Chem. Commun., 2016, 52, 2241 DOI: 10.1039/C5CC09016D

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