Issue 12, 2016
From the journal:

Chemical Communications

MicroRNA-induced cascaded and catalytic self-assembly of DNA nanostructures for enzyme-free and sensitive fluorescence detection of microRNA from tumor cells†

Xue Gong,a   Wenjiao Zhou,a   Yaqin Chai,a   Ruo Yuana  and  Yun Xiang*a  

* Corresponding authors

a Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
E-mail: yunatswu@swu.edu.cn
Fax: +86-23-68252277
Tel: +86-23-68253172

Abstract

The presence of target microRNA triggers cascaded and catalytic self-assembly of two DNA motifs into DNA nanostructures, which serves as a remarkable signal amplification means for the highly sensitive monitoring of the target microRNA and the detection of low numbers of tumor cells.

Graphical abstract: MicroRNA-induced cascaded and catalytic self-assembly of DNA nanostructures for enzyme-free and sensitive fluorescence detection of microRNA from tumor cells

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Article information

DOI
https://doi.org/10.1039/C5CC08861E
Article type
Communication
Submitted
26 Oct 2015
Accepted
21 Dec 2015
First published
22 Dec 2015

Chem. Commun., 2016,52, 2501-2504

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MicroRNA-induced cascaded and catalytic self-assembly of DNA nanostructures for enzyme-free and sensitive fluorescence detection of microRNA from tumor cells

X. Gong, W. Zhou, Y. Chai, R. Yuan and Y. Xiang, Chem. Commun., 2016, 52, 2501 DOI: 10.1039/C5CC08861E

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