Issue 6, 2016

Copper-catalyzed, hypervalent iodine mediated C[double bond, length as m-dash]C bond activation of enaminones for the synthesis of α-keto amides

Abstract

An unprecedented C[double bond, length as m-dash]C bond cleavage of enaminones has been realized by means of copper catalysis in the presence of hypervalent iodine (PhI(OAc)2). The cascade transformation based on this bond cleavage leads to the synthesis of various α-keto amides. Isotope labeling experiments suggest that water has acted as a source of oxygen atoms during the generation of the new carbonyl group.

Graphical abstract: Copper-catalyzed, hypervalent iodine mediated C [[double bond, length as m-dash]] C bond activation of enaminones for the synthesis of α-keto amides

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
24 Oct 2015
Accepted
21 Nov 2015
First published
23 Nov 2015

Chem. Commun., 2016,52, 1270-1273

Author version available

Copper-catalyzed, hypervalent iodine mediated C[double bond, length as m-dash]C bond activation of enaminones for the synthesis of α-keto amides

J. Wan, Y. Lin, X. Cao, Y. Liu and L. Wei, Chem. Commun., 2016, 52, 1270 DOI: 10.1039/C5CC08843G

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