Metalated arylmethylisonitriles readily add to 2-chloropyridines to afford imidazo[1,5-a]pyridines. Analogous additions to imidoyl chlorides and a chloroquinoline provide imidazoles and an imidazo[1,5-a]quinolone which, like imidazo[1,5-a]pyridines, are valuable heterocycles for pharmaceutical synthesis.
![Graphical abstract: Isonitrile alkylations: a rapid route to imidazo[1,5-a]pyridines](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C5CC08724D&imageInfo.ImageIdentifier.Year=2016)
Y. Li, A. Chao and F. F. Fleming, Chem. Commun., 2016, 52, 2111 DOI: 10.1039/C5CC08724D
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