Issue 44, 2016
From the journal:

Chemical Communications

Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells†

Shubhanchi Nigam,ab   Benjamin P. Burke,ab   Laura H. Davies,c   Juozas Domarkas,bd   Jennifer F. Wallis,c   Paul G. Waddell,c   Jennifer S. Waby,e   David M. Benoit,a   Anne-Marie Seymour,de   Christopher Cawthorne,be   Lee J. Higham*c  and  Stephen J. Archibald*ab  

* Corresponding authors

a Department of Chemistry, University of Hull, Cottingham Road, Hull, UK
E-mail: S.J.Archibald@Hull.ac.uk

b Positron Emission Tomography Research Centre, University of Hull, Cottingham Road, Hull, UK

c School of Chemistry, Newcastle University, Bedson Building, Newcastle upon Tyne, UK

d Centre for Cardiovascular and Metabolic Research, University of Hull, Cottingham Road, Hull, UK

e School of Biological, Biomedical and Environmental Sciences, University of Hull, Cottingham Road, UK

Abstract

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.

Graphical abstract: Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

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Article information

DOI
https://doi.org/10.1039/C5CC08325G
Article type
Communication
Submitted
06 Oct 2015
Accepted
25 Apr 2016
First published
26 Apr 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 7114-7117

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Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

S. Nigam, B. P. Burke, L. H. Davies, J. Domarkas, J. F. Wallis, P. G. Waddell, J. S. Waby, D. M. Benoit, A. Seymour, C. Cawthorne, L. J. Higham and S. J. Archibald, Chem. Commun., 2016, 52, 7114 DOI: 10.1039/C5CC08325G

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