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Issue 13, 2016
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Direct phosphonation of quinoxalin-2(1H)-ones under transition-metal-free conditions

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Abstract

A direct C–H bond phosphonation of quinoxalin-2(1H)-ones with H-phosphonates, H-phosphinates or H-phosphine oxides has been developed. A wide variety of heteroaryl phosphonates were obtained in up to 92% yield for 20 examples under transition-metal-free conditions. This protocol tolerates a broad scope of substrates and features practicality, high efficiency, environmental friendliness and atom economy.

Graphical abstract: Direct phosphonation of quinoxalin-2(1H)-ones under transition-metal-free conditions

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The article was received on 25 Sep 2015, accepted on 19 Dec 2015 and first published on 06 Jan 2016


Article type: Communication
DOI: 10.1039/C5CC08049E
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Citation: Chem. Commun., 2016,52, 2846-2849

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    Direct phosphonation of quinoxalin-2(1H)-ones under transition-metal-free conditions

    M. Gao, Y. Li, L. Xie, R. Chauvin and X. Cui, Chem. Commun., 2016, 52, 2846
    DOI: 10.1039/C5CC08049E

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