Issue 8, 2016
From the journal:

Chemical Communications

Synthesis of glycosylphosphatidylinositol (GPI)-anchor glycolipids bearing unsaturated lipids†

B.-Y. Lee,a   P. H. Seebergerab  and  D. Varon Silva*ab  

* Corresponding authors

a Max Planck Institute of Colloids and Interfaces, Biomolecular Systems, Am Mühlenberg 1, 14476 Potsdam, Germany
E-mail: daniel.varon@mpikg.mpg.de

b Department of Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin, Germany

Abstract

2-Naphthyl-methyl ethers as permanent protecting groups are readily removed under acidic conditions and are key to the synthesis of complex glycosylphosphatidylinositol anchors containing unsaturated lipids. The total synthesis of the GPI pseudo-disaccharide core found on the surface of the Trypanosoma cruzi parasite serves to illustrate the power of the strategy.

Graphical abstract: Synthesis of glycosylphosphatidylinositol (GPI)-anchor glycolipids bearing unsaturated lipids

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5CC07694C
Article type
Communication
Submitted
14 Sep 2015
Accepted
27 Nov 2015
First published
30 Nov 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 1586-1589

Permissions

Request permissions

Synthesis of glycosylphosphatidylinositol (GPI)-anchor glycolipids bearing unsaturated lipids

B.-Y. Lee, P. H. Seeberger and D. Varon Silva, Chem. Commun., 2016, 52, 1586 DOI: 10.1039/C5CC07694C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements