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Issue 2, 2016
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Design and synthesis of a new chromophore, 2-(4-nitrophenyl)benzofuran, for two-photon uncaging using near-IR light

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Abstract

A new chromophore, 2-(4-nitrophenyl)benzofuran (NPBF), was designed for two-photon (TP) uncaging using near-IR light. The TP absorption (TPA) cross-sections of the newly designed NPBF chromophore were determined to be 18 GM at 720 nm and 54 GM at 740 nm in DMSO. The TP uncaging reaction of a caged benzoate with the NPBF chromophore quantitatively produced benzoic acid with an efficiency (δu) of ∼5.0 GM at 740 nm. The TP fragmentation of an EGTA unit was observed with δu = 16 GM. This behavior makes the new chromophore a promising TP photoremovable protecting group for physiological studies.

Graphical abstract: Design and synthesis of a new chromophore, 2-(4-nitrophenyl)benzofuran, for two-photon uncaging using near-IR light

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Publication details

The article was received on 14 Sep 2015, accepted on 20 Oct 2015 and first published on 21 Oct 2015


Article type: Communication
DOI: 10.1039/C5CC07664A
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Citation: Chem. Commun., 2016,52, 331-334
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    Design and synthesis of a new chromophore, 2-(4-nitrophenyl)benzofuran, for two-photon uncaging using near-IR light

    N. Komori, S. Jakkampudi, R. Motoishi, M. Abe, K. Kamada, K. Furukawa, C. Katan, W. Sawada, N. Takahashi, H. Kasai, B. Xue and T. Kobayashi, Chem. Commun., 2016, 52, 331
    DOI: 10.1039/C5CC07664A

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