Issue 7, 2016
From the journal:

Chemical Communications

Catalytic self-assembly of a DNA dendritic complex for efficient gene silencing†

Yifan Lv,‡a   Ruizi Peng,‡a   Yu Zhou,a   Xiaobing Zhang*a  and  Weihong Tan*ab  

* Corresponding authors

a Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Molecular Engineering and Theranostics, Hunan University, Changsha 410082, China
E-mail: xbzhang@hnu.edu.cn

b Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA
E-mail: tan@chem.ufl.edu
Fax: +1 352 846 2410

Abstract

A catalytic self-assembled DNA dendritic complex was herein reported and used for siRNA-based gene silencing. This kind of one-pot DNA dendrimer can be conveniently prepared as needed, and it was demonstrated to have better silencing efficiency and lower cytotoxicity than commercial cationic lipid transfection agents.

Graphical abstract: Catalytic self-assembly of a DNA dendritic complex for efficient gene silencing

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5CC06937H
Article type
Communication
Submitted
18 Aug 2015
Accepted
17 Nov 2015
First published
18 Nov 2015

Chem. Commun., 2016,52, 1413-1415

Author version available

Download author version (PDF)

Permissions

Request permissions

Catalytic self-assembly of a DNA dendritic complex for efficient gene silencing

Y. Lv, R. Peng, Y. Zhou, X. Zhang and W. Tan, Chem. Commun., 2016, 52, 1413 DOI: 10.1039/C5CC06937H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements