Issue 2, 2016
From the journal:

Chemical Communications

A polydopamine nanosphere based highly sensitive and selective aptamer cytosensor with enzyme amplification†

Daoqing Fan,ab   Changtong Wu,abc   Kun Wang,abc   Xiaoxiao Gu,abc   Yaqing Liu*abd  and  Erkang Wang*ab  

* Corresponding authors

a State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China
E-mail: ekwang@ciac.ac.cn
Fax: +86-431-85689711
Tel: +86-22-60912484

b University of Chinese Academy of Sciences, Beijing, China

c Department of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun, China

d Key Laboratory of Food Nutrition and Safety (Tianjin University of Science and Technology), Ministry of Education, Tianjin, P. R. China
E-mail: yaqingliu@tust.edu.cn

Abstract

With CCRF-CEM as the model cell, a highly sensitive and selective cytosensor was developed by taking advantage of polydopamine nanospheres for the first time. The strategies of aptamer/membrane protein recognition and Exonuclease III assisted cycle amplification were used for improving selectivity and sensitivity. The detection of limit reached was as low as 15 cells per mL.

Graphical abstract: A polydopamine nanosphere based highly sensitive and selective aptamer cytosensor with enzyme amplification

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Article information

DOI
https://doi.org/10.1039/C5CC06754E
Article type
Communication
Submitted
12 Aug 2015
Accepted
26 Oct 2015
First published
26 Oct 2015

Chem. Commun., 2016,52, 406-409

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A polydopamine nanosphere based highly sensitive and selective aptamer cytosensor with enzyme amplification

D. Fan, C. Wu, K. Wang, X. Gu, Y. Liu and E. Wang, Chem. Commun., 2016, 52, 406 DOI: 10.1039/C5CC06754E

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