Issue 5, 2016

Design of nanomaterial based systems for novel vaccine development

Abstract

With lower cell toxicity and higher specificity, novel vaccines have been greatly developed and applied to emerging infectious and chronic diseases. However, due to problems associated with low immunogenicity and complicated processing steps, the development of novel vaccines has been limited. With the rapid development of bio-technologies and material sciences, nanomaterials are playing essential roles in novel vaccine design. Incorporation of nanomaterials is expected to improve delivery efficiency, to increase immunogenicity, and to reduce the administration dosage. The purpose of this review is to discuss the employment of nanomaterials, including polymeric nanoparticles, liposomes, virus-like particles, peptide amphiphiles micelles, peptide nanofibers and microneedle arrays, in vaccine design. Compared to traditional methods, vaccines made from nanomaterials display many appealing benefits, including precise stimulation of immune responses, effective targeting to certain tissue or cells, and desirable biocompatibility. Current research suggests that nanomaterials may improve our approach to the design and delivery of novel vaccines.

Graphical abstract: Design of nanomaterial based systems for novel vaccine development

Article information

Article type
Review Article
Submitted
05 Nov 2015
Accepted
10 Feb 2016
First published
19 Feb 2016

Biomater. Sci., 2016,4, 785-802

Design of nanomaterial based systems for novel vaccine development

L. Yang, W. Li, M. Kirberger, W. Liao and J. Ren, Biomater. Sci., 2016, 4, 785 DOI: 10.1039/C5BM00507H

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