Jump to main content
Jump to site search

Issue 46, 2016
Previous Article Next Article

Identification of the impurities in 2,5-dimethoxy-4-ethylphenethylamine tablets by high performance liquid chromatography mass spectrometry-ion trap-time of flight

Author affiliations

Abstract

This paper illustrated the identification of relevant impurities in illegal drug 2,5-dimethoxy-4-ethylphenethylamine (2C-E) which can help to regulate this illegal drug and identify the source of their manufacture. Hybrid ion trap/time-of-flight mass spectrometry coupled with high performance liquid chromatography (LC/MS-IT-TOF) is used as an efficient and effective method for qualitative analysis. In this study, the fragment pathway of 2C-E was deduced after the LC-MSn determination of the 2C-E standard by LC/MS-IT-TOF. Ten impurities were detected in the 2C-E tablets using an optimized LC/MS-IT-TOF method. According to the exact mass data of MSn and the analysis of the element composition, the structures of ten impurities were identified. The synthetic route of the 2C-E tablets was proposed by analysis of these impurities. The established method is not only effective in identifying impurities, but also helps to identify the manufacturing source of this illegal drug.

Graphical abstract: Identification of the impurities in 2,5-dimethoxy-4-ethylphenethylamine tablets by high performance liquid chromatography mass spectrometry-ion trap-time of flight

Back to tab navigation

Publication details

The article was received on 30 Jul 2016, accepted on 30 Oct 2016 and first published on 11 Nov 2016


Article type: Paper
DOI: 10.1039/C6AY02162J
Citation: Anal. Methods, 2016,8, 8179-8187
  •   Request permissions

    Identification of the impurities in 2,5-dimethoxy-4-ethylphenethylamine tablets by high performance liquid chromatography mass spectrometry-ion trap-time of flight

    Y. Li, M. Wang, A. Li, H. Zheng and Y. Wei, Anal. Methods, 2016, 8, 8179
    DOI: 10.1039/C6AY02162J

Search articles by author

Spotlight

Advertisements