We demonstrate a rapid, sensitive, and low cost paper-based approach for sperm chromatin integrity analysis that quantifies both DNA fragmentation and packaging. The paper-based test provides identical clinical outcome as the gold standard sperm chromatin structure assay. This technology is fast, simple, and suitable for broad application in clinics.
R. Nosrati, M. M. Gong, M. C. San Gabriel, A. Zini and D. Sinton, Anal. Methods, 2016, 8, 6260 DOI: 10.1039/C6AY01506A
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