Jump to main content
Jump to site search

Issue 19, 2016
Previous Article Next Article

Modification of a disposable pencil graphite electrode with multiwalled carbon nanotubes: application to electrochemical determination of diclofenac sodium in some pharmaceutical and biological samples

Author affiliations

Abstract

A pencil graphite electrode (PGE) modified by multiwalled carbon nanotubes (MWCNTs) was developed as an electrochemical sensor and used for the determination of diclofenac sodium (DIC). The morphological and interfacial properties of the modified electrode were characterized by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS) techniques, respectively. Various strategies for modification of the PGE by MWCNTs were examined and concluded that the drop coating of a non-treated PGE (NPGE) has the best performance. In the following, various parameters which affect the electrochemical performance of the modified electrode toward diclofenac sodium determination such as the pH of buffer solution, type and concentration of buffer solution, and amount of MWCNTs on the electrode surface were studied. Differential pulse voltammetry (DPV) was used for the determination of DIC. Under optimized conditions, a calibration graph was plotted by the variation of anodic peak currents as a function of DIC concentration in the linear range of 0.047–12.95 μM with a detection limit of 0.017 μM (S/N = 3). The MWCNTs/PGE was used for the determination of DIC in real samples, including pharmaceutical and biological samples, and the good accuracy of the modified electrode was confirmed by acceptable recovery values.

Graphical abstract: Modification of a disposable pencil graphite electrode with multiwalled carbon nanotubes: application to electrochemical determination of diclofenac sodium in some pharmaceutical and biological samples

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Feb 2016, accepted on 13 Apr 2016 and first published on 05 May 2016


Article type: Paper
DOI: 10.1039/C6AY00441E
Citation: Anal. Methods, 2016,8, 3966-3974
  •   Request permissions

    Modification of a disposable pencil graphite electrode with multiwalled carbon nanotubes: application to electrochemical determination of diclofenac sodium in some pharmaceutical and biological samples

    G. P. Fard, E. Alipour and R. E. Ali Sabzi, Anal. Methods, 2016, 8, 3966
    DOI: 10.1039/C6AY00441E

Search articles by author

Spotlight

Advertisements