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Issue 25, 2016
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Reduction of matrix effects through a simplified QuEChERS method and using small injection volumes in a LC-MS/MS system for the determination of 28 pesticides in fruits and vegetables

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Abstract

A simplified QuEChERS method coupled with a small injection volume was developed for the simultaneous determination of 28 pesticides in 6 matrices (apples, cucumbers, tomatoes, luffa, cabbages, and eggplants) using LC-MS/MS. In the sample procedure, acetonitrile with 0.1% (v/v) formic acid was used to extract and no depurative powder was used. Three fortified levels (10, 50, and 100 μg kg−1) were determined and the recoveries of 168 analyte/matrix combinations were in the range of 60–120% except for cyromazin, pendimethalin, and fenpropathrin. Half of the 168 LOQs were below 0.1 μg kg−1, and 29 LOQs were above 1 μg kg−1. Moreover, four relationships between signal suppression and injection volume were observed ranging from 0.5 μL to 15 μL. For many analyte/matrix combinations, the matrix effects could be reduced to less than 20% if the injection volume was less than a critical value (named critical volume). The critical volume depending on the initial extent of matrix effects was explored and the conclusion was: for weak or medium MEs, usually ≤2 μL injection volume was needed and for several weak MEs, injection volume ≤ 5 μL can reduce the matrix effect to a negligible level.

Graphical abstract: Reduction of matrix effects through a simplified QuEChERS method and using small injection volumes in a LC-MS/MS system for the determination of 28 pesticides in fruits and vegetables

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Article information


Submitted
13 Jan 2016
Accepted
25 May 2016
First published
09 Jun 2016

Anal. Methods, 2016,8, 5061-5069
Article type
Paper
Author version available

Reduction of matrix effects through a simplified QuEChERS method and using small injection volumes in a LC-MS/MS system for the determination of 28 pesticides in fruits and vegetables

H. Li, C. Wang, Q. Zhu, H. Du, S. Guan, F. Wang, W. Zhang, W. Fan, Z. Chen, G. Yang and H. Y. Aboul-Enein, Anal. Methods, 2016, 8, 5061
DOI: 10.1039/C6AY00080K

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